I believe the Invisible College is one of the most poorly understood books in the 7th Sea series, one that has a lot of background in truth, and very little in the way of power-gaming possibilities, so it gets tossed aside.
In my campaign, I plan on having the Invisible College mix with the Explorer's Society...thus making the Royal Society, which existed in the late 1600's.
I think the biggest trouble inherent in the book is how much research is necessary to make it happen. I say phooey to that. Just have fun...drink potions made of the blood of sorcerers and burst into flames. Invent stuff...dissect dogs...blow up laboratories...journey across Theah in search of brilliant minds...avoid the Inquisition...refine the telescope lens the way Newton did...blow more laboratories up...
last note: Every 7th Sea player could stand to read 'The Baroque Cycle' by Neal Stephenson. It's incredible as reference material.
[4 of 5 Stars!]